IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay

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• 作者：Masato Kadoya^a ; Kenichi Kaida^a ; ^{adiak901@ndmc.ac.jp} ; Haruki Koike^b ; Hiroshi Takazaki^a ; Hidenori Ogata^c ; Kota Moriguchi^a ; Jun Shimizu^d ; Eiichiro Nagata^e ; Shunya Takizawa^e ; Atsuro Chiba^f ; Ryo Yamasaki^c ; Jun-ichi Kira^c ; Gen Sobue^b ; Katsunori Ikewaki^a
• 关键词：Chronic inflammatory demyelinating polyradiculoneuropathy ; Neurofascin155 ; IgG4 ; Antibody ; Enzyme-linked immunosorbent assay
• 刊名：Journal of Neuroimmunology
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：301
• 期：Complete
• 页码：16-22
• 全文大小：716 K
• 卷排序：301

文摘

Anti-Neurofascin155 antibody was measured in CIDP patients by multiple methods. The diagnostic utility of human NF155-based ELISA for screening is validated. Western blot and CBA are useful for confirmation of positive results in ELISA. Development of the optimal treatment will require gathering of more information.