Characterization of pharmacological properties of isolated single-stranded DNA aptamers against angiotensin II
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- 作者：Mohammad Heiata ; Reza Ranjbara ; ranjbarre@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mahdi Fasihi-Ramandia ; Ali Mohammad Latifib ; Mohammad Javad Rasaeec
- 关键词：Cytotoxicity ; Hemolysis ; Immune response ; Serum stability ; ssDNA aptamer
- 刊名：Molecular and Cellular Probes
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：30
- 期：4
- 页码：238-245
- 全文大小：3147 K
文摘
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Some of the pharmacological properties of two high-affinity ssDNA aptamers against angiotensin II peptide were characterized.
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Results confirmed that the aptamers had ignorable toxic potency and immunogenicity even at high concentrations.
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The aptamer with the GC rich and double-stranded regions was more susceptible to serum nuclease activity.
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The structure, sequense composition and motifs were the determinative parameters in aptamer pharmacological properties.