Some of the pharmacological properties of two high-affinity ssDNA aptamers against angiotensin II peptide were characterized.
Results confirmed that the aptamers had ignorable toxic potency and immunogenicity even at high concentrations.
The aptamer with the GC rich and double-stranded regions was more susceptible to serum nuclease activity.
The structure, sequense composition and motifs were the determinative parameters in aptamer pharmacological properties.