Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study

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• 作者：Serafim Tsitsilonis ; MD ; MSc ; PhD^a ; ^b ; ^c ; ^{serafeim.tsitsilonis@charite.de" class="auth_mail} ; Chatzistergos E. Panayiotis ; PhD^d ; Mitousoudis S. Athanasios ; PhD^d ; Kourkoulis K. Stavros ; PhD^d ; Vlachos S. Ioannis ; MSc^a ; Agrogiannis George ; MD^f ; Fasseas Konstantinos ; PhD^e ; Perrea N. Despina ; PhD^a ; Zoubos B. Aristides ; MD ; PhD^g
• 关键词：Anabolic androgenic steroids ; Achilles tendon ; Rupture ; Biomechanics
• 刊名：Foot and Ankle Surgery
• 出版年：June 2014
• 年：2014
• 卷：20
• 期：2
• 页码：94-99
• 全文大小：1195 K

文摘

The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons.

Methods

Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons’ biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed.

Results

In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise.

Conclusions

These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.