Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance
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- 作者：Peter Arner1 ; peter.arner@ki.se" class="auth_mail ; Dominique Langin2 ; 3 ; 4
- 关键词：lipolysis ; triglyceride turnover ; insulin resistance ; obesity ; cancer cachexia
- 刊名：Trends in Endocrinology and Metabolism
- 出版年：May 2014
- 年：2014
- 卷：25
- 期：5
- 页码：255-262
- 全文大小：828 K
文摘
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Adipose tissue lipolysis is an essential catabolic pathway providing energy to the body when needed (e.g., fasting and physical exercise).
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The process is exquisitely regulated by neural, hormonal, and paracrine factors.
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Adipose tissue lipolysis is a determinant of adipose lipid turnover.
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It is dysregulated in obesity, insulin resistance, and cancer cachexia.
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Partial inhibition of adipose tissue lipolysis is a plausible therapeutic strategy in these conditions.