Effects of waterborne Cu exposure on intestinal copper transport and lipid metabolism of Synechogobius hasta
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- 作者：Feng Chena ; Zhi Luoa ; b ; d ; luozhi99@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; luozhi99@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Guang-Hui Chena ; Xi Shia ; Xu Liuc ; Yu-Feng Songa ; Ya-Xiong Pana
- 关键词：ACC ; acetyl-CoA carboxylase ; ANOVA ; one-way analysis of variance ; CPT ; carnitine palmitoyltransferase ; CTR ; copper transporter ; Cu ; copper ; DG ; diacylglycerol ; DMT ; divalent metal transporter ; FA ; fatty acid ; FABP ; fatty acid binding protein ; FAS ; fatty acid synthase ; FATP ; fatty acid transport protein ; G6PD ; glucose-6-phosphate dehydrogenase ; HSL ; hormone-sensitive lipase ; ICDH ; isocitrate dehydrogenase ; IFABP ; intestinal fatty acid binding protein ; ME ; malic enzyme ; MG ; monoacylglycerol ; MT ; m
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：178
- 期：Complete
- 页码：171-181
- 全文大小：1444 K
文摘
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Cu reduced growth performance, and increased intestinal Cu and lipid contents.
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Increased Cu content resulted from genes’ expression involved in Cu transport.
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Cu exposure up-regulated lipogenesis, lipolysis and FA uptake in the intestine.
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Up-regulation of lipolysis resulted from metabolic expenditure after Cu exposure.
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Cu exposure increased intestinal lipid accumulation despite increased lipolysis.