Preparation of (2R, 3R, 4R)-3-hydroxy-2,4,6-trimethylheptanoic acid via enzymatic desymmertization

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• 作者：Yoshinori Tokairin ; Hiroyuki Konno ; ^{konno@yz.yamagata-u.ac.jp}
• 关键词：Cyclicdepsipeptide ; Fatty acyl unit ; Enantioselective enzymatic desymmertization
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：73
• 期：1
• 页码：39-45
• 全文大小：498 K
• 卷排序：73

文摘

Synthesis of a unique fatty acyl unit to build the N-terminus of callipeltin A and homophymine B is described. Our approach to access (2R, 3R, 4R)-3-hydroxy-2,4,6-trimethylheptanoic acid uses enzymatic hydrolysis for the desymmetrization of achiral acetate, followed by diastereoselective Roush crotylboration and Wittig olefination for the backbone construction.