Tributyltin chloride increases phenylephrine-induced contraction and vascular stiffness in mesenteric resistance arteries from female rats
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- 作者：Rogé ; rio Faustino Ribeiro Jú ; niora ; rogeriofaustinoribeiro@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Vinicius Bermond Marquesa ; Dieli Oliveira Nunesa ; Karoline de Sousa Ronconia ; Julia F.P. de Araú ; job ; Paula Lopes Rodriguesa ; Alessandra Simã ; o Padilhaa ; Dalton Valentim Vassalloa ; Jones B. Gracelib ; Ivanita Stefanona
- 关键词：Tributyltin chloride ; Endothelial dysfunction ; Oxidative stress ; Arterial remodelling ; Resistance artery
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：295
- 期：Complete
- 页码：26-36
- 全文大小：1428 K
文摘
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Tributyltin chloride reduces estrogen levels in female rats.
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Treatment with TBT resulted in increased contractile response to phenylephrine.
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Collagen deposition could be responsible for vascular stiffness after TBT exposure.