Targeting triple negative breast cancer cells by N³-substituted 9,10-Phenanthrenequinone thiosemicarbazones and their metal complexes

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• 作者：Zahra Afrasiabi ; Preston Stovall ; Kristen Finley ; Amitava Choudhury ; Charles Barnes ; Aamir Ahmad ; Fazlul Sarkar ; Alok Vyas ; Subhash Padhye
• 关键词：9 ; 10-Phenanthrenequinone ; N3-substituted thiosemicarbazones ; Triple negative breast cancer ; Copper complex ; Antiproliferative activity
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：114
• 期：Complete
• 页码：114-119
• 全文大小：776 K

文摘

Novel N³-substituted 9,10-Phenanthrenequinone thiosemicarbazones and their copper, nickel and palladium complexes are structurally characterized and reported along with the single crystal X-ray structures of three ligands and one nickel complex. All compounds were evaluated for their antiproliferative potential against Triple Negative Breast Cancer (TNBC) cells which have poor prognosis and no effective drugs to treat with. All compounds exhibited antiproliferative activity against these cells. Among the metal complexes evaluated, redox active copper complexes were found to be more potent. The possible mechanism for such enhanced activity can be attributed to the generation of oxidative stress, which was amenable for targeting through metal complexation.