Investigating white matter fibre density and morphology using fixel-based analysis

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• 作者：David A. Raffelt^a ; ^{david.raffelt@florey.edu.au} ; J.-Donald Tournier^b ; ^c ; Robert E. Smith^a ; David N. Vaughan^a ; ^d ; ^e ; Graeme Jackson^a ; ^d ; ^f ; Gerard R. Ridgway^g ; ^h ; Alan Connelly^a ; ^d ; ^e
• 关键词：AFD ; apparent fibre density ; CHARMED ; composite hindered and restricted model of diffusion ; CUSP-MFM ; cube and sphere multi-fascicle model ; DWI ; diffusion-weighted imaging ; FA ; fractional anisotropy ; FC ; fibre-bundle cross-section ; FD ; fibre density ; FDC ; fibre density & cross-section ; Fixel ; A specific fibre population within a voxel ; FBA ; fixel-based analysis. ; FBM ; fixel-based morphometry ; FOD ; fibre orientation distribution ; FWE ; family-wise error ; FWHM ; full width at half maximum ; MRI ; magn
• 刊名：NeuroImage
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：144
• 期：part_PA
• 页码：58-73
• 全文大小：4440 K
• 卷排序：144

文摘

A fixel is defined as a specific fibre population within a voxel. We describe a comprehensive approach to fixel-based analysis (FBA) of white matter. A novel method to investigate fibre bundle morphology (cross-section) is presented. We compare fibre density, cross-section and a combined measure in a clinical cohort. The three different analyses give unique yet complementary information.