Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation
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- 作者：Jun Chena ; Xiaoyun Wub ; Shiyou Chena ; Shuliang Chena ; Nian Xianga ; Yu Chena ; Deyin Guoa ; c ; dguo@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fbw7 ; NS5B ; Ubiquitination ; Degradation ; HCV replication
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：470
- 期：3
- 页码：697-703
- 全文大小：1771 K
文摘
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Fbw7 promoted the ubiquination of NS5B and negatively regulated its turnover.
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Fbw7 altered its cellular location when NS5B was present.
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Knockdown of Fbw7 promotes HCV replication while exogenous expression of Fbw7 can suppress HCV replication.