Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin

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• 作者：Saverio Francesco Retta^a ; ^b ; ^{francesco.retta@unito.it} (Prof.) ; Angela J. Glading^c ; ^{Angela_Glading@urmc.rochester.edu}
• 关键词：CCM ; cerebral cavernous malformation ; fCCM ; familial form of CCM ; sCCM ; sporadic form of CCM ; NVU ; neurovascular unit ; ICH ; intracerebral hemorrhage ; ROS ; reactive oxygen species ; COX-2 ; cycloxygenase-2 ; AJ ; adherens junction ; EndMT ; endothelial-to-mesenchymal transition ; TGFβ ; transforming growth factor beta ; BMP ; bone morphogenetic protein ; VEGF ; vascular endothelial growth factor ; KLF ; Kruppel-like factor
• 刊名：The International Journal of Biochemistry & Cell Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：81
• 期：part_PB
• 页码：254-270
• 全文大小：2126 K
• 卷排序：81

文摘

CCM proteins play pleiotropic roles in various redox-sensitive signaling pathways. CCM proteins modulate the crosstalk between redox signaling and autophagy that govern cell homeostasis and stress responses. Oxidative stress and inflammation are emerging as key focal determinants of CCM lesion formation, progression and severity. The pleiotropic functions of CCM proteins may prevent vascular dysfunctions triggered by local oxidative stress and inflammatory events. The distinct therapeutic compounds proposed so far for CCM disease share the ability to modulate redox signaling and autophagy.