Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells
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- 作者：Mª ; del Mar Blanquer-Rosselló ; Reyniel Herná ; ndez-Ló ; pez ; Pilar Roca ; Jordi Oliver ; jordi.oliver@uib.es ; Adamo Valle
- 关键词：ΔΨm ; mitochondrial membrane potential ; 2-DG ; 2-deoxyglucose ; 5-FU ; 5-fluorouracil ; ANT A ; antimycin A ; COX ; cytochrome c oxidase ; ERα ; estrogen receptor alpha ; ERβ ; estrogen receptor beta ; ERRα ; estrogen-related receptor alpha ; ETO ; etomoxir ; FCCP ; carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone ; LDH ; lactate dehydrogenase ; MDC ; monodansylcadaverine ; mtDNA ; mitochondrial DNA ; MTG ; MitoTracker Green® ; MTT ; thiazolyl blue tetrazolium bromide ; NAC ; N-acetyl cysteine ; NAO ; 10-nonyl acridine
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：1861
- 期：2
- 页码：431-440
- 全文大小：936 K
- 卷排序：1861
文摘
Resveratrol exerts cytotoxic effects in SW620 colon cancer cells. Along with cytotoxicity, resveratrol triggers mitochondrial recruitment. Increased mitochondrial machinery results in increased functionality. Enhanced mitochondrial functionality is fueled by increased fatty acid oxidation Resveratrol enhances oxidative metabolism which induces ROS-mediated apoptosis.