The importance of regulatory RNAs in Staphylococcus aureus
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- 作者：Arnaud Tomasini ; Patrice Fran莽ois ; Benjamin P. Howden ; Pierre Fechter ; Pascale Romby ; Isabelle Caldelari
- 关键词：Staphylococcus ; Regulatory RNA ; Virulence
- 刊名：Infection, Genetics and Evolution
- 出版年：January, 2014
- 年：2014
- 卷：21
- 期：Complete
- 页码：616-626
- 全文大小：1284 K
文摘
RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.