Validation of ⁶⁸Ge/⁶⁸Ga generator processing by chemical purification for routine clinical application of ⁶⁸Ga-DOTATOC

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• 作者：Mattia Asti ; Giovanni De Pietri ; Aless ; ro Fraternali ; Elisa Grassi ; Roberto Sghedoni ; Federica Fioroni ; Frank Roesch ; Annibale Versari ; Diana Salvo
• 关键词：⁶⁸Ge/⁶⁸Ga generator ; Postprocessing of eluates ; Cation-exchange chromatography ; DOTATOC ; PET
• 刊名：Nuclear Medicine and Biology
• 出版年：2008
• 出版时间：August 2008
• 年：2008
• 卷：35
• 期：6
• 页码：721-724
• 全文大小：121 K

文摘

Introduction

Imaging of somatostatin receptor expressing tumours has been greatly enhanced by the use of ⁶⁸Ga-DOTATOC and PET/CT.

Methods

In this work, a purification method for the ⁶⁸Ge/⁶⁸Ga generator eluate and a method to produce ⁶⁸Ga-DOTATOC suitable for clinical use were evaluated. The generator eluate was purified and concentrated on a cation-exchange cartridge in HCl/acetone media. The efficacy of this procedure in eliminating metal impurities from the ⁶⁸Ga solution was investigated by ICP-MS. The radiotracer quality was evaluated by radio-TLC, GC and γ-ray spectrometry.

Results

⁶⁸Ga-DOTATOC preparations (n=33) were carried out with a mean synthesis yield of 59.3±2.8 % (not corrected for decay) and a batch activity ranging from 555 to 296 MBq. The radiochemical and radionuclidic purity were >98 % and 99.9999 % , respectively. With this purification process, >95 % of the Fe(III), Zn(II) and Mn(II) were eliminated from the solution.

Conclusions

⁶⁸Ga-DOTATOC produced with this method can be efficiently used in nuclear medicine departments for PET evaluations.