Reduction of catheter-related bloodstream infections in preterm infants by the use of catheters with the AgION antimicrobial system

详细信息    查看全文

• 作者：Giovanna Bertini ; Serena Elia ; Federica Ceciarini ; Carlo Dani ; ^{cdani@unifi.It}
• 关键词：BPD ; bronchopulmonary dysplasia ; BSI ; blood stream infection ; CoNS ; coagulase-negative staphylococci ; CRBSI ; catheter related blood stream infection ; CVC ; central venous catheter ; IVH ; intraventricular hemorrhage ; MV ; mechanical ventilation ; NICU ; neonata
• 刊名：Early Human Development
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：89
• 期：1
• 页码：21-25
• 全文大小：238 K

文摘

Objective

The present study aims to assess if use of a silver zeolite-impregnated umbilical catheter (AgION technology) can decrease the occurrence of catheter-related bloodstream infection (CRBSIs) in preterm infants.

Study design

Infants with gestational age < 30 weeks were randomized to receive an AgION impregnated or non-impregnated polyurethane umbilical venous catheter (UVC). The primary endpoint was the incidence of CRBSIs during the time the UVC was in place.

Results

We studied 86 infants, 41 of whom received the AgION catheter and 45 the non-impregnated catheter. During umbilical venous catheterization 2 % of infants in the AgION group developed CRBSI in comparison with 22 % of infants in the control group (p = 0.005). AgION catheters were well tolerated and none of the patients showed signs attributable to silver toxicity.

Conclusions

The AgION-impregnated UVCs were effective in decreasing the development of CRBSIs in preterm infants compared to non-impregnated polyurethane UVCs.