Role of nanostructured aggregation of chitosan derivatives on [5-methionine]enkephalin affinity

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• 作者：Federica Aiello^a ; ^{federica.aiello87@gmail.com} ; Federica Balzano^a ; ^{federica.balzano@unipi.it} ; Luca Carpita^a ; ^{lucarpita@hotmail.it} ; Angela Fabiano^b ; ^{angyfab@gmail.com} ; Ylenia Zambito^b ; ^{ylenia.zambito@unipi.it} ; Gloria Uccello Barretta^a ; ^{gloria.uccello.barretta@unipi.it}
• 关键词：Nuclear magnetic resonance ; Nanoparticles ; Chitosan conjugates ; Selective relaxation rate ; [5-Methionine]enkephalin
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：321-324
• 全文大小：438 K
• 卷排序：157

文摘

NMR was employed for affinity and mucoadhesivity studies and release processes. [5-Methionine]enkephalin affinity for chitosan derivatives was investigated. Chitosan-based nanoparticles show enhanced drug affinity and mucoadhesivity. Very high nanoparticles stability was detected.