Actions of methylphenidate on dopaminergic neurons of the ventral midbrain

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• 作者：Federici ; Mauro ; Geracitano ; Raffaella ; Bernardi ; Giorgio ; Mercuri ; Nicola B.
• 关键词：ADHD ; methylphenidate ; dopamine ; DAT ; ventral midbrain ; synaptic transmission
• 刊名：Biological Psychiatry
• 出版年：2005
• 出版时间：February 15, 2005
• 年：2005
• 卷：57
• 期：4
• 页码：361-365
• 全文大小：266 K

文摘

Methylphenidate has been suggested to exert its therapeutic effect mainly by blocking the dopamine transporter. In spite of the importance of this interaction, no detailed information is available yet on its actions on single dopaminergic neurons.