A Role for Timp3 in Microbiota-Driven Hepatic Steatosis and Metabolic Dysfunction
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- 作者：Maria Mavilio1 ; 7 ; Valentina Marchetti1 ; 7 ; Marta Fabrizi1 ; 2 ; Robert Stö ; hr1 ; 3 ; Arianna Marino1 ; Viviana Casagrande1 ; Loredana Fiorentino1 ; Marina Cardellini1 ; Ben Kappel1 ; 3 ; Ivan Monteleone4 ; Celine Garret5 ; Alessandro Mauriello4 ; Giovanni Monteleone1 ; Alessio Farcomeni6 ; Remy Burcelin6 ; Rossella Menghini1 ; Massimo Federici1 ; federicm@uniroma2.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：16
- 期：3
- 页码：731-743
- 全文大小：4409 K
文摘
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Loss of Timp3 combined with an HFD affects glucose tolerance and innate immunity
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Timp3−/− mice exhibit gut dysbiosis, liver steatosis, and systemic inflammation
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Defective BCAA metabolism in Timp3−/− mice contributes to the metabolic phenotype
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Gut microbiome modulation by antibiotics rescues inflammatory and metabolic status