Synthesis and antiproliferative activity of peracetylated 2-amino-1,2-dideoxy-1-nitro-d-glycero-l-manno and d-glycero-d-talo heptitols
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- 作者：Veró ; nica Luque-Agudoa ; Ana Marí ; a Gonzá ; lez Gutié ; rreza ; Irene Lagunesb ; Federico Ló ; pez Galindoa ; José ; M. Padró ; nb ; Emilio Romá ; na ; José ; Antonio Serranoa ; Marí ; a Victoria Gila ; vgil@unex.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Stereoselectivity ; Nitroalkenes ; Amines ; Michael reactions ; Carbohydrates ; Antiproliferative activity
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：71-76
- 全文大小：569 K
文摘
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New Michael adducts derived from carbohydrates were synthetized.
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In the case of d-galacto nitroalkene synthesis was diastereoselective.
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Antiproliferative activity of some of new compounds was evaluated.
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Two products showed better values than 5-fluorouracil against two tumor cell lines.