In silico modeling of malaria and sickle-cell disease

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• 作者：Dmitry A. Fedosov ^{d.fedosov@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Drug Discovery Today: Disease Models
• 出版年：2015
• 出版时间：Summer 2015
• 年：2015
• 卷：16
• 期：Complete
• 页码：17-22
• 全文大小：782 K

文摘

In silico modeling of hematologic diseases and disorders (e.g., malaria, sickle cell anemia) has proved to make a significant contribution to the understanding of various disease processes and their progression. This review presents a general computational framework for modeling blood flow on a single cell level applied here to malaria and sickle cell disease. The computational disease model is validated using several independent experimental results. The simulation approach is general enough to address a broad range of issues related to hematologic diseases and disorders with implications for diagnostics and treatment.