Palladium-catalysed reactions of 6-halogeno-1,1′-binaphthyl derivatives. A detailed investigation of structure/reactivity and structure/selectivity relationships
详细信息 查看全文
- 作者：Csaba Fehé ; r<sup>asup> ; Bé ; la Urbá ; n<sup>asup> ; Lá ; szló ; Ü ; rge<sup>bsup> ; Ferenc Darvas<sup>bsup> ; Jó ; zsef Bakos<sup>asup> ; Rita Skoda-Fö ; ldes<sup>asup><sup> ; sup><sup>skodane@almos.uni-pannon.hu"" rel=""nofollowsup>
- 关键词：1 ; 1′ ; -Binaphthyl derivatives ; Palladium ; Coupling reactions ; Carbonylation
- 刊名：Tetrahedron
- 出版年：2011
- 出版时间：26 August 2011
- 年：2011
- 卷：67
- 期：34
- 页码：6327-6333
- 全文大小：352 K
文摘
Five 6-halogeno-binaphthyl derivatives of different structure were synthesised starting from 2,2′-dihydroxy-1,1′-binaphthyl 1. Several new 6-substituted binaphthyl compounds were obtained via the palladium-catalysed reactions of these derivatives. The reactivity of 6-iodo derivatives was much greater in most cases. In cross-coupling reactions the 6-bromo compounds were converted into the products using longer reaction times and/or higher temperatures. The reactivity difference between the two types of substrates was especially marked in aminocarbonylation and Heck reactions.