Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides

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• 作者：Iris Amitay-Laish ; MD^a ; Ronit Sarid ; PhD^b ; Dan Ben-Amitai ; MD^c ; ^e ; Inna Kalt ; PhD^b ; Shiri Rivka Masa ; MSc^b ; Michael David ; MD^a ; ^e ; Meora Feinmesser ; MD^d ; ^e ; Emmilia Hodak ; MD^a ; ^e ; ^{hodake@post.tau.ac.il}
• 关键词：familial ; human herpesvirus 8 ; juvenile ; lymphoma ; mycosis fungoides ; parapsoriasis ; skin cancer
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：66
• 期：1
• 页码：46-50
• 全文大小：106 K

文摘

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Background

Human herpesvirus (HHV) 8, an essential etiologic agent of Kaposi sarcoma, is also associated with several lymphoproliferative disorders. The involvement of HHV 8 in mycosis fungoides (MF) and large plaque parapsoriasis (LPP) is controversial, with contradictory reports from various countries worldwide.

Objective

We sought to investigate the presence of the HHV 8 genome in skin lesions of LPP and early-stage sporadic, familial, and juvenile MF in patients in Israel.

Methods

Archival paraffin-embedded and frozen samples from skin biopsies of untreated patients with LPP and early-stage MF performed in 1990 through 2006 were randomly collected from the department of dermatology of a tertiary medical center in central Israel. DNA was extracted, and a TaqMan-based real-time polymerase chain reaction assay specific for the K6 gene region was used to detect the HHV 8 genome.

Results

A total of 46 biopsies were sampled from 11 patients with LPP and 35 with early-stage MF (17?adults with sporadic MF, 10 children, and 8 patients with familial MF). In all, 44 samples were negative for HHV 8 DNA; two samples from adults with sporadic MF were positive.

Limitations

The presence of HHV 8 antibodies or virus sequences was not assessed in peripheral blood.

Conclusion

The results of this study, conducted in a region relatively endemic for HHV 8, support most earlier studies showing a lack of association of HHV 8 infection with LPP and sporadic adult-type MF. To our knowledge, the lack of association of HHV 8 infection with juvenile and familial MF has not been previously reported.