Triazole fungicide tebuconazole disrupts human placental trophoblast cell functions
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- 作者：Jinghua Zhoua ; Jianyun Zhangb ; Feixue Lic ; Jing Liua ; b ; jliue@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Triazole fungicides ; Tebuconazole ; Trophoblast ; Toxicity ; Invasion
- 刊名：Journal of Hazardous Materials
- 出版年：2016
- 出版时间：5 May 2016
- 年：2016
- 卷：308
- 期：Complete
- 页码：294-302
- 全文大小：2864 K
文摘
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Tebuconazole (TEB) inhibited the proliferation of human placental trophoblasts.
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TEB changed cell cycle distribution of G1 and G2 phases of trophoblasts.
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TEB induced apoptosis of trophoblasts via mitochondrial pathway.
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TEB decreased the invasive and migratory capacities of trophoblasts.
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TEB altered the mRNA levels of key regulatory genes in trophoblasts