Possible mechanisms of Pseudomonas aeruginosa-associated lung disease

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• 作者：Cassiano Felippe Gonç ; alves-de-Albuquerque^a ; ^{cassianofg@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Adriana Ribeiro Silva^a ; Patrí ; cia Burth^b ; Patricia Rieken Macê ; do Rocco^c ; Mauro Velho Castro-Faria^d ; ¹ ; Hugo Caire Castro-Faria-Neto^a ; ¹
• 关键词：Pseudomonas aeruginosa ; Lung injury ; Inflammation
• 刊名：International Journal of Medical Microbiology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：306
• 期：1
• 页码：20-28
• 全文大小：2452 K

文摘

m>Pseudomonas aeruginosam> is an opportunistic bacterium causing lung injury in immunocompromised patients correlated with high morbidity and mortality. Many bacteria, including m>P. aeruginosam>, use extracellular signals to synchronize group behaviors, a process known as quorum sensing (QS). In the m>P. aeruginosam> complex QS system controls expression of over 300 genes, including many involved in host colonization and disease. m>P. aeruginosam> infection elicits a complex immune response due to a large number of immunogenic factors present in the bacteria or released during infection. Here, we focused on the mechanisms by which m>P. aeruginosam> triggers lung injury and inflammation, debating the possible ways that m>P. aeruginosam> evades the host immune system, which leads to immune suppression and resistance.