Herpes simplex virus colitis complicating ulcerative colitis: A case report and brief review on superinfections

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• 作者：Marco Oliver Schunter^a ; ^{marco.schunter@rbk.de} ; Thorsten Walles^b ; Peter Fritz^c ; Uta Meyding-Lamadé ; ^c ; ^d ; Klaus-Peter Thon^b ; Klaus Fellermann^a ; Eduard Friedrich Stange^a ; Wolfram Lamadé ; ^b
• 关键词：Herpes simplex virus ; Ulcerative colitis ; Aciclovir
• 刊名：Journal of Crohn's and Colitis
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：1
• 期：1
• 页码：41-46
• 全文大小：951 K

文摘

In patients with inflammatory bowel disease herpes simplex virus infection has been described as a major cause of morbidity and mortality, especially in immunocompromised individuals. Here we present the case of a 35-year old woman with an exacerbation of ulcerative colitis caused by herlpes simplex virus infection (HSV-2). The diagnosis was confirmed histologically following subtotal colectomy. After intravenous treatment with aciclovir for 2?weeks postoperative hematochezia stopped. Herpes simplex virus colitis is a rare but potentially fatal complication of immunosuppressive treatment in patients with inflammatory bowel disease. Prompt diagnosis and efficient antiviral therapy are mandatory to improve prognosis.