Linear IgA dermatosis induced by a new angiotensin-converting enzyme inhibitor

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• 作者：Felice Femiano ; Crispian Scully ; Fern ; o Gombos
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
• 出版年：2003
• 出版时间：February 2003
• 年：2003
• 卷：95
• 期：2
• 页码：169-173
• 全文大小：167 K

文摘

A 68-year-old female patient treated with benazepril for arterial hypertension developed oral and cutaneous blistering. Biopsy of the oral and cutaneous lesions showed neutrophilic microabscesses in the mesenchymal papillae, with epitheliomesenchymal separation. Direct immunofluorescence revealed linear immunoglobulin deposits at the epithelial basement membrane zone, consisting predominantly of IgA. The histologic results supported the clinical diagnosis of drug-induced linear IgA disease. The substitution of benazepril with a beta blocker resulted in complete resolution of all mucocutaneous lesions. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:169-73)