A comparison of salivary substitutes versus a natural sialogogue (citric acid) in patients complaining of dry mouth as an adverse drug reaction: a clinical, randomized controlled study

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• 作者：Felice Femiano MDM ; PhD^a ; ^{femiano@libero.it"" rel=""nofollow} ; Rosario Rullo MDMDr^a ; Federica di Spirito DDSDr^a ; Alessandro Lanza DDS ; MScDr^a ; Vincenzo Maria Festa DDS ; MScDr^a ; Nicola Cirillo DDS ; PhD^b
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
• 出版年：2011
• 出版时间：July 2011
• 年：2011
• 卷：112
• 期：1
• 页码：e15-e20
• 全文大小：333 K

文摘

Objective

We aimed to compare the efficacy of saliva substitutes and citric acid long-term therapy for oral dryness relief and unstimulated salivary flow in patients reporting drug-induced xerostomia.

Study design

Fifty-four patients reporting drug-induced xerostomia were randomly subdivided into 3 groups and respectively administered artificial saliva, 3 % citric acid, or distilled water in mouthwash 4 times a day for 30 days. Patients underwent measurement of unstimulated whole saliva before and after they finished therapy and were asked to note in a daily diary any symptomatologic changes 15 minutes and 1 hour after each daily intake of test solution.

Results

Fifteen minutes after solution intake, 12 patients (67 % ) belonging to the artificial saliva group, 9 (50 % ) from the citric acid group, and 2 (11 % ) from the water group reported significant symptomatologic improvement. One hour after solution intake, 7 patients (39 % ) from the artificial saliva group, 10 (56 % ) from the citric acid group, and 0 from the water group noted significant symptomatologic improvement. None of the drugs tested affected unstimulated whole saliva flow.

Conclusions

Both artificial saliva and citric acid provided immediate relief from oral dryness. Citric acid also provided a longer-lasting feeling of oral moistness at 1 hour after use owing to its protracted activity on salivary gland function.