Traceless liquid-phase synthesis of 3-alkylamino-4,5-disubstituted-1,2,4-triazoles on polyethylene glycol (PEG)

详细信息    查看全文

• 作者：Zong ; Ying-Xiao ; Wang ; Jun-Ke ; Yue ; Guo-Ren ; Feng ; Lei ; Song ; Zheng-En ; Song ; Hai ; Han ; Yu-Qi
• 关键词：Poly(ethylene glycol) (PEG) ; 3-Alkylamino-4 ; 5-disubstituted-1 ; 2 ; 4-triazoles ; Arylacyl thiourea ; Benzoyl hydrazine ; Liquid-phase synthesis
• 刊名：Tetrahedron Letters
• 出版年：2005
• 出版时间：August 1, 2005
• 年：2005
• 卷：46
• 期：31
• 页码：5139-5141
• 全文大小：110 K

文摘

A liquid-phase route to 3-alkylamino-4,5-disubstituted-1,2,4-triazoles has been developed, which permits the incorporation of three elements of diversity. The heterocycle was constructed upon PEG6000 (soluble polymer) modified by 4-hydroxy-2-methoxybenzaldehyde, from which a traceless cleavage could be realized with TFA/CH₂Cl₂. This method provided a library of 3-alkylamino-4,5-disubstituted-1,2,4-triazoles with reasonable yields and excellent purity.