DNA tetrahedral scaffolds-based platform for the construction of electrochemiluminescence biosensor

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• 作者：Qiu-Mei Feng ; Zhen Zhou ; Mei-Xing Li ; Wei Zhao ; ^{weizhao@nju.edu.cn} ; Jing-Juan Xu ; ^{xujj@nju.edu.cn} ; Hong-Yuan Chen
• 关键词：DNA tetrahedral scaffolds ; Electrochemiluminescence ; Surface plasmon resonance ; CdS quantum dots ; Au nanoparticles
• 刊名：Biosensors and Bioelectronics
• 出版年：2017
• 出版时间：15 April 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：251-257
• 全文大小：778 K
• 卷排序：90

文摘

A DNA tetrahedral scaffold-based platform for the construction of ECL biosensor is designed. DNA tetrahedron provides necessary space for TSP extending and subsequent assembly of luminol labelled Au NPs. Telomerase from HeLa cells was sensitively detected by the ECL enhancement from both CdS QDs and luminol. This work suggests that DNA tetrahedral scaffolds serve as an excellent choice for the construction of SPR-ECL system.