Activation of LXR attenuates collagen-induced arthritis via suppressing BLyS production
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- 作者：Yan Huanga ; b ; Xiaohong Fua ; Xilin Lyua ; Zhizhen Xua ; Zhicheng Hec ; Yan Zhanga ; Yijun Zenga ; Fengtian Hea ; hefengtian2010@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Gang Huanga ; cqhuanggang@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Liver X receptor ; Arthritis ; B-lymphocyte stimulator ; B lymphocyte ; Gene regulation
- 刊名：Clinical Immunology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：161
- 期：2
- 页码：339-347
- 全文大小：1316 K
文摘
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Administration of GW3965 suppressed BLyS production to ameliorate CIA in DBA/1 mice.
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GW3965 inhibited the basal and IFNγ/TGFβ-induced BLyS expression in vitro.
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Activation of LXR suppressed NF-κB binding to the promoter region of BLyS gene.
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GW3965 repressed IFNγ-induced STAT1 activation and TGFβ-induced SMAD3 activation.