Plk2 promotes tumor growth and inhibits apoptosis by targeting Fbxw7/Cyclin E in colorectal cancer
详细信息 查看全文
- 作者：Baochi Oua ; b ; 1 ; Jingkun Zhaoa ; b ; 1 ; Shaopei Guana ; b ; Xiongzhi Wangpua ; Congcong Zhua ; b ; Yaping Zonga ; Junjun Maa ; Jing Suna ; Minhua Zhenga ; b ; Hao Fenga ; c ; fenghaoobc@163.com" class="auth_mail" title="E-mail the corresponding author ; Aiguo Lua ; b ; weichuang_lu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Colorectal cancer ; Plk2 ; Fbxw7 ; Cyclin E
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：380
- 期：2
- 页码：457-466
- 全文大小：4199 K
文摘
- •
Plk3 was lowly expressed, whereas Plk2 was expressed highly in tumor tissues compared to paired normal tissues.
- •
Plk2 was previously reported as a tumor suppressor gene, while our findings suggest an oncogenic role for Plk2 in colorectal cancer.
- •
Plk2 represents an independent marker for predicting prognosis of colorectal cancer patients.
- •
Plk2 promotes tumor growth and inhibits apoptosis by targeting Fbxw7/Cyclin E pathway.