Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients
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- 作者：Jia-jia Liua ; 1 ; Jun-yan Liua ; 1 ; Jun Chena ; Yi-xi Wua ; Peng Yana ; Cheng-dong Jib ; Yan-xia Wangb ; Dong-fang Xiangb ; Xia Zhangb ; Peng Zhangb ; You-hong Cuib ; Ji Ming Wangb ; c ; Xiu-wu Bianb ; bianxiuwu@263.net" class="auth_mail" title="E-mail the corresponding author ; Feng Qiana ; qianfengpuwaia@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Scinderin ; Gastric cancer ; Invasion ; Metastasis ; Filopodia ; Cdc42
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：376
- 期：1
- 页码：110-117
- 全文大小：2658 K
文摘
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High levels of SCIN expression in GC tissue predict a poor outcome in patients.
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SCIN enhances the invasive and metastatic capabilities of GC cells in vitro and in vivo.
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Filopodium formation is involved in the SCIN- promoted invasion and metastasis of GC cells.
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Suppression of SCIN in GC cells is accompanied by decreased expression of Cdc42, an important regulator of filopodia.