Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes

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• 作者：Orsolya Dö ; mö ; tö ; r^a ; ^b ; Rodrigo F.M. de Almeida^c ; Leonor Cô ; rte-Real^d ; Cristina P. Matos^d ; ^e ; Fernanda Marques^f ; Antó ; nio Matos^g ; Carla Real^c ; Tamá ; s Kiss^a ; ^b ; É ; va Anna Enyedy^a ; M. Helena Garcia^d ; Ana Isabel Tomaz^d ; ^{isabel.tomaz@ciencias.ulisboa.pt}
• 关键词：Antitumor ; Ru(III)-bis(aminophenolate) complexes ; Ru(III)-salan complexes ; DNA binding constants ; Cell cycle arrest ; Apoptosis ; Cell morphology
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：27-37
• 全文大小：1846 K
• 卷排序：168

文摘

Metal complexes with bis(aminophenolate) ligands are also known as salan-complexes. Two anti-tumor Ru(III)-salan-complexes induce apoptotic processes in cancer cells. A novel quantitative approach for DNA binding is applied to evaluate their interaction. The in vitro biological action depends on their phenolate ring substituent position. Effects on cell-cycle and organelle morphology differ for these Ru(III)-salan-complexes.