Rationale and design of the First Brazilian Cardiovascular Registry of Atrial Fibrillation: The RECALL study

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• 作者：Renato D. Lopes ; MD ; PhD ; MHS^a ; ^b ; ^c ; ^{renato.lopes@duke.edu" class="auth_mail" title="E-mail the corresponding author} ; Angelo Amato Vicenzo de Paola ; MD^b ; ^c ; Adalberto Menezes Lorga Filho ; MD^d ; ^e ; Fernanda Marciano Consolim-Colombo ; MD^b ; ^f ; ^g ; Jadelson Andrade ; MD^b ; Luiz Alberto Piva e Mattos ; MD^b ; Sabrina Bernardez-Pereira ; MD ; MSc^h ; Otá ; vio Berwanger ; MD ; PhD^h ; Marcio Jansen de Oliveira Figueiredo ; MD^d ; ⁱ ; on behalf of the RECALL Steering Committee ; Investigators
• 刊名：American Heart Journal
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：176
• 期：Complete
• 页码：10-16
• 全文大小：303 K

文摘

Atrial fibrillation (AF) is an important and growing public health problem worldwide, but data about its actual prevalence, therapeutic management, and clinical outcomes in middle- to low-income countries are scarce.

Design

The First Brazilian Cardiovascular Registry of Atrial Fibrillation (the RECALL study) will assess demographic characteristics and evidence-based practice of a representative sample of patients with AF in Brazil. The prospective, multicenter registry has a planned sample size of around 5,000 patients at approximately 80 sites. Eligibility criteria include age >18 years and permanent, paroxysmal, or persistent AF documented by electrocardiogram, 24-hour Holter monitoring, or device interrogation. Patients will be followed up through 1 year after enrollment. Information on laboratory tests, echocardiographic data, medication use, and clinical outcomes will be obtained. Various aspects of the population will be described, including demographic characteristics; antithrombotic therapies; antiarrhythmic agents; level of control of international normalized ratio (by average time within the therapeutic range) among patients using vitamin K antagonists; rates of warfarin discontinuation; outcomes such as death, stroke, systemic embolism, and major bleeding within 1 year after enrollment in the study; and rates of electrical cardioversion, percutaneous ablation of AF, ablation of the atrioventricular junction, and pacemaker/cardioverter-defibrillator implantation.

Summary

RECALL is the first prospective, multicenter registry of AF in Brazil. This study will provide important information about demographics, practice patterns, treatments, and associated outcomes in patients with AF. The results of this registry will also allow Brazilian data to be put in perspective with other AF registries across the world and provide opportunities to improve care of patients with AF in Brazil.