Genetic structure of Mexican Mestizos with type 2 diabetes mellitus based on three STR loci

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• 作者：Ricardo M. Cerda-Flores^a ; ^{ricardocerda_mx@yahoo.com.mx} ; Roxana A. Rivera-Prieto^b ; ^{roxriveraprieto@hotmail.com} ; Benito Pereyra-Alfé ; rez^b ; ^{bpereyra@gmail.com} ; Ana L. Calderó ; n-Garcidueñ ; as^c ; ^{acald911@hotmail.com} ; Hugo A. Barrera-Saldañ ; a^d ; ^{habarrera@gmail.com} ; Hugo L. Gallardo-Blanco^e ; ^{hugoleonid2008@gmail.com} ; Rocí ; o Ortiz-Ló ; pez^f ; ^{rortizlopez@gmail.com} ; Yolanda Flores-Peñ ; a^a ; ^{yflores_mx@yahoo.com.mx} ; Velia M. Cá ; rdenas-Villarreal^a ; ^{velia_margaritac@hotmail.com} ; Fernando Rivas^g ; ^{genesmx@hotmail.com} ; André ; s Figueroa^h ; ^{andresfila@utpa.edu} ; Gautam Kshatriyaⁱ ; ^{g26_51@yahoo.co.in}
• 关键词：CHIH. ; Chihuahua ; CRMx ; Central Region of Mexico ; DF ; Degree of freedom ; DM ; Type 2 diabetes mellitus ; Exp. ; Expected ; Gst ; Total genetic diversity ; Ht ; Total average gene diversity ; HWE ; Hardy&ndash ; Weinberg expectations ; IMSS ; Mexican Institute of Socia
• 刊名：Gene
• 出版年：2013
• 出版时间：1 August, 2013
• 年：2013
• 卷：525
• 期：1
• 页码：41-46
• 全文大小：399 K

文摘

Background

The aims of this population genetics study were: 1) to ascertain whether Mexicans with type 2 diabetes mellitus (DM) were genetically homogeneous and 2) to compare the genetic structure of this selected population with the previously reported data of four random populations (Nuevo Le¨®n, Hispanics, Chihuahua, and Central Region of Mexico).

Methods

A sample of 103 unrelated individuals with DM and whose 4 grandparents were born in five zones of Mexico was interviewed in 32 Medical Units in the Mexican Institute of Social Security (IMSS). The non-coding STRs D16S539, D7S820, and D13S317 were analyzed.

Results

Genotype distribution was in agreement with Hardy-Weinberg expectations for all three markers. Allele frequencies were found to be similar between the selected population and the four random populations. Gene diversity analysis suggested that more than 99.57 % of the total gene diversity could be attributed to variation between individuals within the population and 0.43 % between the populations.

Conclusions

According to the present and previous studies using molecular and non-molecular nuclear DNA markers not associated with any disease, the Mexican Mestizo population is found to be genetically homogeneous and therefore the genetic causes of DM are less heterogeneous, thereby simplifying genetic epidemiological studies as has been found in a previous study with the same design in Mexican women with breast cancer.