Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction
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- 作者：José ; M. Muñ ; oz-Fé ; lixa ; b ; 1 ; 2 ; jmmb@usal.es" class="auth_mail" title="E-mail the corresponding author ; j.munoz-felix@qmul.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Lucí ; a Pé ; rez-Roquea ; b ; 1 ; Elena Nú ; ñ ; ez-Gó ; meza ; b ; 1 ; Bá ; rbara Oujoa ; b ; Miguel Aré ; valoc ; Laura Ruiz-Remolinaa ; b ; Cristina Cuestaa ; b ; Carmen Langad ; Fernando Pé ; rez-Barriocanala ; b ; Carmelo Bernabeud ; José ; M. Lopez-Novoaa ; b
- 关键词：α-SMA ; α-smooth muscle actin ; ALK1 ; activin receptor-like kinase 1 ; ALK5 ; activin receptor-like kinase 5 ; ANOVA ; analysis of variance ; ECM ; extracellular matrix ; Eng ; endoglin ; ICAM-1 ; intercellular cell adhesion molecule-1 ; NO ; non-obstructed ; O ; obstructed ; PDGF ; Platelet-Derived Growth Factor ; SEM ; standard error of the mean ; TGF-β1 ; transforming growth factor-β1 ; VCAM-1 ; vascular cell adhesion molecule-1 ; UUO ; unilateral ureteral obstruction ; WT ; wild type
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1801-1814
- 全文大小：2896 K
文摘
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Overexpression of S-Eng kidney reduces fibrosis in the ureteral obstruction model.
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Overexpression of S-Eng reduces myofibroblast abundance and inflammation in the ureteral-ligated kidney.
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Overexpression of S-Eng decreases the activation of TGF-β/Smad pathways in the kidney after ureteral obstruction.