Overview and perspectives on the transcriptome of Paracoccidioides brasiliensis

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• 作者：Rosâ ; ngela V. Andrade¹ ; Silvana P. da Silva² ; Fernando A.G. Torres¹ ; Marcio José ; Poç ; as-Fonseca¹ ; Ildinete Silva-Pereira¹ ; Andrea Q. Maranhã ; o¹ ; É ; lida G. Campos¹ ; Lí ; dia Maria P. Moraes¹ ; Rosá ; lia S.A. Jesuí ; no³ ; Maristela Pereira³ ; Cé ; lia M.A. Soares³ ; Maria Emí ; lia M.T. Walter¹ ; Maria José ; A. Carvalho¹ ; Nalvo F. Almeida⁴ ; Marcelo M. Brí ; gido¹ ; Maria Sueli S. Felipe¹ ; ^{msueli@unb.br}
• 关键词：Transcriptome ; Expressed Sequence Tags ; Dimorphic and thermo-regulated fungus ; Paracoccidioides brasiliensis
• 刊名：Revista Iberoamericana de Micolog¨ªa
• 出版年：2005
• 出版时间：December 2005
• 年：2005
• 卷：22
• 期：4
• 页码：203-212
• 全文大小：193 K

文摘

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Summary

Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America that affects 10 million individuals. Pathogenicity is assumed to be a consequence of the dimorphic transition from mycelium to yeast cells during human infection. This review shows the results of the P. brasiliensis transcriptome project which generated 6,022 assembled groups from mycelium and yeast phases. Computer analysis using the tools of bioinformatics revealed several aspects from the transcriptome of this pathogen such as: general and differential metabolism in mycelium and yeast cells; cell cycle, DNA replication, repair and recombination; RNA biogenesis apparatus; translation and protein fate machineries; cell wall; hydrolytic enzymes; proteases; GPI-anchored proteins; molecular chaperones; insights into drug resistance and transporters; oxidative stress response and virulence. The present analysis has provided a more comprehensive view of some specific features considered relevant for the understanding of basic and applied knowledge of P. brasiliensis.