Cell differentiation and the multiple drug resistance phenotype in human erythroleukemic cells
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- 作者：Michele Carrett-Diasa ; b ; Leda Karine Almeidab ; Juliano Lacava Pereirac ; Daniela Volcan Almeidad ; Daza Moraes Vaz Batista Filgueirab ; Luis Fernando Marinsa ; d ; Ana Paula de Souza Vottoa ; b ; anavotto@furg.br" class="auth_mail" title="E-mail the corresponding author ; Gilma Santos Trindadea ; b
- 关键词：Leukemia ; MDR ; Alox-5 ; Differentiation ; Tumoral stem cell ; PMA
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：13-20
- 全文大小：1873 K
文摘
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PMA not induces differentiation to megakaryocytes in Lucena cells.
Alox-5 gene is suggested to be related to differentiation erythroleukemic cells.
Firsthand Alox-5, Mdr1, Nanog, Oct-4 and Sox-2 genes expression in FEPS cells was seen.
Oct-4 and Sox-2 gene expression is similar in MDR cell lines.
Alox-5 gene is expressed reversed to Mdr1 gene in erythroleukemic cell lines.