Effects of a 6-days-a-week low protein diet regimen on depressive symptoms in young-old type 2 diabetic patients

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• 作者：Tiziana Ciarambino ; Nicoletta Ferrara ; Pietro Castellino ; Giuseppe Paolisso ; Ludovico Coppola ; Mauro Giordano
• 关键词：Low protein dietary ; Type 2 diabetes ; Depression ; Elderly
• 刊名：Nutrition
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：27
• 期：1
• 页码：46-49
• 全文大小：149 K

文摘

Objectives

Late-life depression is one of the main health problems among elderly diabetic subjects. In addition, depression is a common psychopathological condition among renal failure patients and most of these patients follow a low protein diet regimen (LPD). However, the effects of LPD on depressive symptoms are unclear.

Design

In the present study, the effects of LPD regimen on depressive symptoms in elderly type 2 diabetic subjects with renal failure were investigated.

Participants

Fifty-two young-old type 2 diabetic patients with renal failure were enrolled in the study. All participants after normal protein diet regimen providing 1.2 g/kg per d were instructed to consume either a LPD providing 0.8 g/kg per d, 7 d a wk (LPD 7/7), or a LPD providing 0.8 g/kg per d 6 d a wk (LPD 6/7) randomly.

Results

Mean 15-item Geriatric Depression Scale (GDS-15) (2.0 ± 0.6) and Beck Depression Inventory (BDI) (4.1 ± 1.0), during normal protein diet regimen, significantly increased to (6.7 ± 1.6) and (12.2 ± 1.4), respectively, after LPD 7/7 (P < 0.05 versus normal protein diet). However, after LPD 6/7, mean GDS-15 and BDI significantly decreased to (4.4 ± 1.5) and (6.7 ± 1.6), respectively (P < 0.05 versus LPD 7/7).

Conclusion

LPD 6/7 regimen significantly decreased depressive symptoms in young-old type 2 diabetic patients.