Partially hydrolyzed guar gum increases intestinal absorption of iron in growing rats with iron deficiency anemia

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• 作者：Karine de Cá ; ssia Freitas ; Olga Maria Silvé ; rio Amancio ; Neil Ferreira Novo ; Ulysses Fagundes-Neto ; Mauro Batista de Morais
• 关键词：Dietary fiber ; Intestinal absorption ; Iron deficiency anemia ; Rats
• 刊名：Clinical Nutrition
• 出版年：2006
• 出版时间：October 2006
• 年：2006
• 卷：25
• 期：5
• 页码：851-858
• 全文大小：192 K

文摘

The objective of this study was to evaluate the effect of partially hydrolyzed guar gum (PHGG) dietary fiber towards intestinal iron absorption, for dietary intake and on the growth of rats with iron deficiency anemia in comparison to those fed on a diet with cellulose and without dietary fiber.

Materials and methods

Male Wistar rats (n=24) weaned at 21 days were fed with AIN93-G diet without iron for 2 weeks in order to induce iron deficiency anemia. At 36 days old, the anemic rats were divided into three groups: (1) PHGG group—100 g of PHGG per kg of diet; (2) Cellulose group—100 g of cellulose per kg of diet; (3) Control group—diet without dietary fiber. All the diets had 25 mg of elemental iron/kg of diet added to lead to recovery from iron deficiency anemia.

Results

The final hemoglobin values in g/dl, for the PHGG group, the cellulose group and the control group were, respectively: 11.3±1.2, 8.6±0.7 and 8.1±0.9 (P<0.001). The levels of hepatic iron, in μg/g of dry tissue, in the same order, were: 322.2±66.6, 217.2±59.1 and 203.7±42.4 (P<0.001). Apparent iron intestinal absorption was, respectively: 67.5±8.9 % , 35.4±15.3 % and 31.3±24.9 % (P<0.001). The three groups consumed similar quantities of diet. The changes in weight and in body length were similar in the three groups studied.

Conclusion

PHGG led to greater intestinal absorption of iron, regeneration of hemoglobin and hepatic levels of iron than diet with cellulose and diet control.