The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells

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• 作者：Florencia Marcucci¹ ; ⁴ ; Veronica Murcia-Belmonte² ; ⁴ ; Qing Wang¹ ; ⁵ ; Yaiza Coca² ; Susana Ferreiro-Galve² ; Takaaki Kuwajima¹ ; Sania Khalid¹ ; M. Elizabeth Ross³ ; Carol Mason¹ ; ⁶ ; ^{cam4@columbia.edu} ; Eloisa Herrera² ; ^{e.herrera@umh.es}
• 关键词：retinal progenitors ; ipsilateral RGCs ; contralateral RGCs ; Cyclin D2 ; ciliary margin zone ; neurogenesis ; retina ; binocular vision
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：3153-3164
• 全文大小：4656 K
• 卷排序：17

文摘

Live imaging of E14 mouse retina reveals cells moving from the CMZ to the RGC layer Cyclin D2 is enriched in the ventral CMZ Neurogenesis and RGC numbers are reduced in Cyclin D2−/− neural retina Perturbations in the albino CMZ further link the CMZ to RGC production