The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks
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- 作者：Sang Hoon Ha1 ; Sun Young Kim1 ; James E. Ferrell Jr.1 ; 2 ; james.ferrell@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：14
- 期：6
- 页码：1408-1421
- 全文大小：3896 K
文摘
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Cks2 regulates the phosphorylation of Wee1A by Cdk1 in a biphasic manner
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This biphasic regulation accounts for Cks overexpression phenotypes
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Cks2 changes the balance in the mutual inhibition of Cdk1 and Wee1A