Gadolinium toxicity: Iron and ferroportin as central targets

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• 作者：Sundararaman Swaminathan ^{swami@virginia.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Gadolinium ; Toxicity ; Iron ; Ferroportin ; Brain ; Macrophage
• 刊名：Magnetic Resonance Imaging
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：34
• 期：10
• 页码：1373-1376
• 全文大小：377 K

文摘

Gadolinium-based magnetic resonance (MR) contrast agents (GBCM) causes a devastating systemic fibrosing illness, nephrogenic systemic fibrosis (NSF), in patients with reduced kidney function. GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF. GBCA might similarly target iron-rich, ferroportin-expressing structures such as globus pallidus and cerebellar dentate nucleus in the brain to result in metal accumulation and potential toxicity.