Coffee polyphenols improve peripheral endothelial function after glucose loading in healthy male adults

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• 作者：Ryuji Ochiai ; Yoko Sugiura ; Yasushi Shioya ; Kazuhiro Otsuka ; Yoshihisa Katsuragi ; Teruto Hashiguchi
• 关键词：3-CQA ; 3-caffeoylquinic acid ; 4-CQA ; 4-caffeoylquinic acid ; 5-CQA ; 5-caffeoylquinic acid ; 3 ; 4-diCQA ; 3 ; 4-dicaffeoylquinic acid ; 3 ; 5-diCQA ; 3 ; 5-dicaffeoylquinic acid ; 4 ; 5-diCQA ; 4 ; 5-dicaffeoylquinic acid ; 3-FQA ; 3-feruloylquinic acid ; 4-FQA ; 4-feruloylquinic acid ; 5-FQA ; 5-feruloylquinic acid ; BP ; blood pressure ; CPP ; coffee polyphenol ; CQAs ; Chlorogenic acids ; FMD ; flow-mediated dilation ; Glu ; glucose ; RHI ; reactive hyperemia index ; ROS ; reactive oxygen species
• 刊名：Nutrition Research
• 出版年：February, 2014
• 年：2014
• 卷：34
• 期：2
• 页码：155-159
• 全文大小：295 K

文摘

Brewed coffee is a widely consumed beverage, and many studies have examined its effects on human health. We investigated the vascular effects of coffee polyphenols (CPPs), hypothesizing that a single ingestion of CPP during glucose loading would improve endothelial function. To test this hypothesis, we conducted a randomized acute clinical intervention study with crossover design and measured reactive hyperemia index (RHI) to assess the acute effects of a 75-g glucose load with CPP in healthy, nondiabetic adult men. Blood glucose and insulin levels were elevated after glucose loading with and without CPP, with no significant differences between treatments. The RHI did not significantly decrease after glucose loading without CPP. With CPP, however, RHI significantly (P < .05) increased over baseline after glucose loading. The difference between treatments was statistically significant (P < .05). No significant changes were observed in an oxidative stress marker after glucose loading with or without CPP. These findings suggest that a single ingestion of CPP improves peripheral endothelial function after glucose loading in healthy subjects.