Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: Association study in 2000 Dutch Caucasians
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- 作者：Steven J.R. Meex ; Jana V. van Vliet-Ostaptchouk ; Carla J.H. van der Kallen ; Marleen M.J. van Greevenbroek ; Casper G. Schalkwijk ; Edith J.M. Feskens ; Ellen E. Blaak ; Cisca Wijmenga ; Marten H. Hofker ; C
- 关键词：Genetic association study ; Single nucleotide polymorphism ; Familial combined hyperlipidemia ; Complex genetic diseases ; Type 2 diabetes ; Insulin resistance
- 刊名：Molecular Genetics and Metabolism
- 出版年：2008
- 出版时间：July 2008
- 年：2008
- 卷：94
- 期：3
- 页码：352-355
- 全文大小：227 K
文摘
Type 2 diabetes shares substantial genetic and phenotypic overlap with familial combined hyperlipidemia. Upstream stimulatory factor 1 (USF1), a well-established susceptibility gene for familial combined hyperlipidemia, is postulated to be such a shared genetic determinant. We evaluated two established variants in familial combined hyperlipidemia (rs2073658 and rs3737787) for association with type 2 diabetes in two Dutch case-control samples (N = 2011). The first case-control sample comprised 501 subjects with type 2 diabetes from the Breda cohort and 920 healthy blood bank donors of Dutch Caucasian origin. The second case-control sample included 211 subjects with type 2 diabetes, and 379 normoglycemic controls. SNP rs2073658 and SNP rs3737787 were in perfect linkage disequilibrium. In the first case-control sample, prevalence of the major allele was higher in patients than in controls (75 % versus 71 % , OR = 1.25, p = 0.018). A similar effect-size and -direction was observed in the second case-control sample (76 % versus 72 % , OR = 1.22, p = 0.16). A combined analysis strengthened the evidence for association (OR = 1.23, p = 0.006). Notably, the increased risk for type 2 diabetes could be ascribed to the major allele, and its high frequency translated to a substantial population attributable risk of 14.5 % .