Serum 25-Hydroxyvitamin D Is Associated With Cognitive Executive Function in Dutch Prefrail and Frail Elderly: A Cross-Sectional Study Exploring the Associations of 25-Hydroxyvitamin D With Glucose Metabolism, Cognitive Performance and Depression

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• 作者：Elske M. Brouwer-Brolsma ; Ondine van de Rest ; Michael Tiel ; Nikita L. van der Zwaluw ; Wilma T. Steegenga ; Jos J. Adam ; Luc J.C. van Loon ; Edith J.M. Feskens ; Lisette C.P.G.M. de Groot
• 关键词：Vitamin D ; glucose metabolism ; cognition ; depression ; aging ; cross-sectional
• 刊名：Journal of the American Medical Directors Association
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：14
• 期：11
• 页码：852.e9-852.e17
• 全文大小：301 K

文摘

Objectives

The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH]D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels.

Design, Setting, and Participants

Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65?years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria.

Measurements

Associations of 25(OH)D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression.

Results

No associations were observed for 25(OH)D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH)D was positively associated with executive functioning (¦Â 0.007, m>Pm>?=?.01) and tended to be associated with information-processing speed (¦Â 0.006, m>Pm>?=?.06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression.

Conclusion

This cross-sectional study suggests an association of serum 25(OH)D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated.