A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion
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- 作者：Alexandre Picard1 ; Josselin Soyer1 ; Xavier Berney1 ; David Tarussio1 ; Simon Quenneville1 ; Maxime Jan2 ; Eric Grouzmann3 ; Fré ; dé ; ric Burdet2 ; Mark Ibberson2 ; Bernard Thorens1 ; 4 ; bernard.thorens@unil.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：genetic screen ; glucose sensing ; QTL mapping ; FGF15 ; FGF19 ; hypothalamus ; dorsal vagal complex ; neuroglucopenia ; glucagon secretion ; autonomic nervous system
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：17
- 期：7
- 页码：1795-1806
- 全文大小：2427 K
文摘
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Recombinant inbred mice screened for QTLs associated with glucagon secretion
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Combined QTL and transcriptomic analysis suggests a role for hypothalamic Fgf15
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Fgf15 i.c.v. blunts neuroglucopenia-induced vagal nerve firing and glucagon secretion
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Silencing Fgf15 mRNA in the dorsomedial hypothalamus increases glucagon secretion