A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/− mice
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- 作者：Jingzhong Zhanga ; 1 ; Jingzhong.Zhang@mdc-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Sebastian Gö ; tza ; sebastian.goetz@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Daniela M. Vogt Weisenhorna ; b ; c ; daniela.vogt@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Antonio Simeoned ; e ; antonio.simeone@igb.cnr.it" class="auth_mail" title="E-mail the corresponding author ; Wolfgang Wursta ; b ; c ; f ; wurst@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Nilima Prakasha ; b ; 2 ; nilima.prakash@hshl.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain-derived neurotrophic factor ; BSA ; bovine serum albumin ; BS(s) ; binding site(s) ; cCASP3 ; cleaved (activated) caspase 3 ; ChIP ; chromatin immunoprecipitation ; DA ; dopamine ; dopaminergic ; DKK3 ; Dickkopf homolog 3 ; DIV ; day(s) in vitro ; EN1 ; Engrailed 1 ; FGF20 ; fibroblast growth factor 20 ; FZD1 ; Frizzled 1 ; GSK3β ; glycogen synthase kinase 3 beta ; HD ; homeodomain ; IHC/ICC ; immunohistochemistry/immunocytochemistry ; ISH ; in situ hybridization ; LEF1 ; lymphoid enhancer binding factor 1 ; LMX1A
- 刊名：Neurobiology of Disease
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：82
- 期：Complete
- 页码：32-45
- 全文大小：2515 K
文摘
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Ectopic Wnt1 expression rescues En1 mutant DA neurodegeneration.
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Ectopic Wnt1 activates direct and indirect WNT/β-catenin target genes.
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En1 mutant DA neuroprotection is provided by the secreted WNT targets BDNF and DKK3.