Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish

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• 作者：Hajime Yamauchi¹ ; ^a ; Mami Goto¹ ; ^a ; Mika Katayama^a ; Ayumi Miyake^a ; Nobuyuki Itoh ; ^a ; ^{itohnobu@pharm.kyoto-u.ac.jp"" rel=""nofollow}
• 关键词：Fgf ; Fgf20b ; Cranial neural crest ; Pharyngeal arch ; Ectomesenchyme ; Zebrafish
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2011
• 出版时间：17 June 2011
• 年：2011
• 卷：409
• 期：4
• 页码：705-710
• 全文大小：1147 K

文摘

In cranial skeletal development, the establishment of the ectomesenchymal lineage within the cranial neural crest is of great significance. Fgfs are polypeptide growth factors with diverse functions in development and metabolism. Fgf20b knockdown zebrafish embryos showed dysplastic neurocranial and pharyngeal cartilages. Ectomesenchymal cells from cranial neural crest cells were significantly decreased in Fgf20b knockdown embryos, but cranial neural crest cells with a non-ectomesnchymal fate were increased. However, the proliferation and apoptosis of cranial neural crest cells were essentially unchanged. Fgfr1 knockdown embryos also showed dysplastic neurocranial and pharyngeal cartilages. The present findings indicate that Fgf20b is required for ectomesenchymal fate establishment via the activation of Fgfr1 in zebrafish.