刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:29 January 2017
年:2017
卷:483
期:1
页码:442-448
全文大小:1867 K
卷排序:483
文摘
EFhd2 is an actin-binding protein in the central nervous and immune systems of mammals. We created a core domain phospho-mimicking mutant of the EFhd2 (CDEFhd2S183E). The crystal structure of CDEFhd2S183E was solved at 1.86 Å. S183E changes the conformational dynamics and the surface charge distribution of the actin-binding sites. We propose a model for the phosphorylation-dependent modulation of actin dynamics by EFhd2.